Protective Effect of Polyphenols Extract of Adlay (<em>Coix lachryma-jobi </em>L. var<em>. ma-yuen Stapf</em>) on Hypercholesterolemia-Induced Oxidative Stress in Rats

Protective Effect of Polyphenols Extract of Adlay (<em>Coix lachryma-jobi </em>L. var<em>. ma-yuen Stapf</em>) on Hypercholesterolemia-Induced Oxidative Stress in Rats

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The present study examines the effect of polyphenols extract of adlay (<em>Coix lachryma-jobi </em>L.var.<em> ma-yuen Stapf</em>) (APE) on high cholesterol diet fed rats (HCD).APE was orally administrated by gavage at doses of 10, 40 and 200 mg total phenolics/kg body Transfer Equipment - Benches weight of rats once a day for 28 days.

At the end of four weeks, serum triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C), and markers of oxidative stress <em>viz</em>., malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in the serum and liver of HCD and normal rats were assessed and compared.The results showed that administration of APE was significantly effective in decreasing the serum levels of TC, LDL-C and MDA, increasing the serum level of HDL-C and antioxidant capacity.In addition, oral gavage of APE could also increase the antioxidant capacity, CAT and GSH-Px activities in liver.

These results suggested that APE exerted a high hypocholesterolemic and antioxidant Right Arm activities, which might be characterized by a protective effect on cardiovascular health <em>in vivo</em>.